One function could be coding for proteins another function could be acting as a ‘molecular switch’ that regulates the operation of other genes. To reach that conclusion, ENCODE systematically scouted the genome as a whole for specific functions. After working hard for almost a decade, in 2012 ENCODE came to a surprising conclusion: rather than being composed mostly of useless junk, 80 per cent of the human genome is in fact functional. To answer this question, hundreds of scientists worldwide joined a massive science project called the Encyclopedia of DNA Elements, or ENCODE. It emerged that roughly half our DNA consisted of ‘repeats’, long stretches of letters sometimes found in millions of copies at seemingly random places throughout the genome. What about the other 97 per cent? With the publication of the first draft of the human genome in 2001, that shadow world came into focus. Yet DNA that codes for such known structures accounts for just over 3 per cent of our genome. These genes contain recipes for molecules, especially proteins, that are the main building blocks and molecular machines of our bodies. Our genome has more than 20,000 genes, relatively stable stretches of DNA transmitted largely unchanged between generations. Yet science has served up the confounding paradox that the bulk of our genome appears to be dead wood, biologically inert junk.Ĭould all this mysterious ‘dark matter’ in our genome really be non-functional?
Humans are astounding creatures, our unique and highly complex traits encoded by our genome – a vast sequence of DNA ‘letters’ (called nucleotides) directing the building and maintenance of the body and brain.
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